NEW DRUGS IN DERMATOLOGY Prof Dr Claude FAVROT A new class of insecticides: Isoxazoline Isoxazoline is a new class of potent insecticides including Fluralaner, afoxolaner and sarolaner
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Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs.
Afoxolaner is an isoxazoline compound characterized by a good safety profile and extended effectiveness against fleas and ticks on dogs following a single oral administration. In vitro membrane feeding assay data and in vivo pharmacokinetic studies in dogs established an afoxolaner blood concentration of 0.1-0.2 μg/ml to be effective against both fleas (Ctenocephalides felis) and ticks (Dermace...
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Highly functionalized 5-trifluoromethyl-2-isoxazoline derivatives featuring a triflyl (SO2CF3) group at the 4-position were successfully synthesized via diastereoselective trifluoromethylation and halogenation of isoxazole triflones using the Ruppert- Prakash reagent. The trifluoromethylation is quite general in terms of the substrates including 3,5-diaryl isoxazole triflones and 3-aryl-5-styry...
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Abstract Bicornuate uterus is class IV and septate uterus is class Vin uterine anomaly classification. Bicornuate uterus is almost always treated by laparotomy and metroplasty. But the treatment of choice for septate uterus is hysteroscopic metroplasty. Bicornuate- septate uterus which is described in this paper is a new class of uterine anomaly(between class IV & V). The advantages of hyster...
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Among the present classes of calcium channel blockers, dihydropyridine derivatives are widely used in the therapy of hypertension, angina pectoris and the other cardiovascular diseases. Since the prototype of dihydropyridine derivatives, nifedipine, does not have the optimum pharmacokinetic and pharmacodynamic characteristics, several attempts have been made to synthesize other drugs in this ...
متن کاملA Class of Convergent Series with Golden Ratio Based on Fibonacci Sequence
In this article, a class of convergent series based on Fibonacci sequence is introduced for which there is a golden ratio (i.e. $frac{1+sqrt 5}{2}),$ with respect to convergence analysis. A class of sequences are at first built using two consecutive numbers of Fibonacci sequence and, therefore, new sequences have been used in order to introduce a new class of series. All properties of the se...
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